GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs1577917 | 1 | rs1337844 | chr6:86677273 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.37 | 2.92E-7 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs1337850 | chr6:86729103 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -5.75 | 4.69E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9309473 | 1 | rs13383871 | chr2:73631779 | ALMS1P | chr2:73872046-73912692:+ | 0.46 | 5.24 | 5.16E-7 | Metabolite levels |
| UCEC | cis | rs2241437 | 1 | rs13390702 | chr2:86237935 | LOC90784 | chr2:86247339-86250991:- | -0.7 | -6.51 | 1.04E-9 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs9309473 | 1 | rs13398956 | chr2:73720258 | ALMS1P | chr2:73872046-73912692:+ | 0.46 | 5.45 | 2.03E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs13421462 | chr2:73719875 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.46 | 1.93E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs13428235 | chr2:73633430 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.13 | 7.2E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs13431267 | chr2:73782200 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.45E-7 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs13432605 | chr2:73810981 | ALMS1P | chr2:73872046-73912692:+ | 0.49 | 5.73 | 5.35E-8 | Metabolite levels |
| UCEC | cis | rs12681963 | 1 | rs1355412 | chr8:29985683 | MBOAT4 | chr8:29989188-30002200:- | 0.51 | 4.76 | 4.49E-6 | Migraine |
| UCEC | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | ANAPC13 | chr3:134196547-134204865:- | 0.38 | 4.37 | 2.26E-5 | Height |
| UCEC | cis | rs1432723 | 1 | rs1368326 | chr5:155296497 | PPP1R2P3 | chr5:156277549-156279539:+ | 0.4 | 4.48 | 1.46E-5 | Obesity-related traits |
| UCEC | cis | rs2028299 | 1 | rs1371135 | chr15:90391270 | AP3S2 | chr15:90373832-90456222:- | -0.47 | -4.87 | 2.8E-6 | Type 2 diabetes |
| UCEC | cis | rs1577917 | 1 | rs1415753 | chr6:86753074 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -5.66 | 7.26E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs10461617 | 1 | rs1423620 | chr5:56100996 | C5orf35 | chr5:56205103-56213010:+ | 0.47 | 5.57 | 1.1E-7 | Type 2 diabetes |